Inflammation, in its broadest sense, is the body’s response to tissue injury. Acute inflammation is typically of short duration, is nonspecific, and may be triggered by any injury. On the other hand, when the inflammation has a slow onset and persists for weeks or months it is referred to as chronic. A major difference between acute and chronic inflammation is that the former is restricted to a specific tissue or organ, whereas the latter affects the lining of the blood vessels throughout the body. In this sense, chronic inflammation is systemic. Chronic, systemic inflammation has been implicated as a major causative factor for several major diseases, including cardiovascular disease, retinopathy, nephropathy, and neuropathy. Detection of chronic inflammation is essential in order to prevent and control these disease processes. This course is designed to help clinicians understand the underlying physiological mechanisms that lead to chronic, systemic inflammation so that they may be more capable of assisting patients in avoiding unnecessary suffering, disability, and expense.

Discusses the historical incidents that led to the discovery of vitamin D. Recognizes the synthesis and function of various forms of inactive and active vitamin D. Describes the role that vitamin D may play in the physiological function of various systems. Lists the current guidelines for supplementation of vitamin D. Lists the blood levels that define the various categories of vitamin D deficiency and sufficiency. Identifies the best food sources of vitamin D.

Identifies clinical signs & symptoms of inflammation. Describes the connections between inflammatory processes and chronic illness. Describes the role of inflammation in specific illnesses such as heart disease, COPD, diabetes, arthritis, and dementia. Lists practical strategies to reduce levels of inflammation in clinical practice. Explains the rationale for good dental prophylaxis and skin care in patients with chronic illness. Describes how the information in this course can be utilized to improve patient care and patient outcomes. Describes, for this course, the implications for dentistry, mental health, and other health professions.